This is a rare type II autoimmune disease in which antibodies are attacking red blood cells have improved activity at temperatures of less than 99 ° F (37.2 ° C). The term Agglutinin refers to an antibody which causes that the antigens, such as red blood cells or bacteria, each with one another to comply with.
Cold agglutinins with low thermal capacity are usually associated with direct red blood cell agglutination (adhesion) at low body temperatures in the peripheral blood vessels network (i.e. the ships outside the circuit of main network). Cold limbs or other peripheral blood clotting phenomena are initiated or reinforced by exposure to cold.
Fixation of complement hemolysis (version Hemogloblin appears in the bloodstream when a red blood cell) is a warm reactive process at high body temperatures; therefore patients have very high concentrations of cold agglutinins, but these antibodies may not be in a position, hemolysis of red blood cells (erythrocytes) in the warmer temperatures, which reached into the bloodstream.
The most cold agglutinins causing little or even no shortening of the life span of red blood cells. High thermal amplitude of cold agglutinins (rarely) long term hemolysis can lead, but the resulting anaemia is often mild and stable. Exposure to cold can bond the cold agglutinins and complement-mediated release of hemoglobin within the vessels (intravascular hemolysis).
A low titer (concentration test) by naturally occurring cold agglutinins (typically 01:32 or less) you can this but without clinical significance in healthy cats. The disease has a genetic basis; Average age and range, racial and gender preferences are unknown. The condition is rather in colder climates occur.
History of cold ExposureAcrocyanosis (travelled skin) associated with, the red blood cells of mud clumps in the vascular network of the SkinErythema (redness of the skin) skin ulceration (equipped with secondary drying / necrosis) dry, gangrenous necrosis of ear tips, tip of the tail, nose and FeetAffected areas may PainfulAnemia may or may not be obvious: associated with pallor, weakness, jaundice, tachycardia (rapid heart beat), tachypnea (rapid breathing), change in skin color, mild splenomegaly (enlargement of the spleen) and soft heart MurmurPrimary disease idiopathic (unknown) secondary disease in cats - connected to the upper respiratory tract InfectionCold Exposure is a risk factorYour vet performs a thorough physical examination on your cat taking into account the background history of the symptoms and possible errors that could have resulted in this State. Diagnosis is made by the historical relics, such as the exposure to the cold, the results of the physical examination, and cold agglutination (adhesion of red blood cells) in vitro evidence.
Skin changes make the tips of the ears and tail, nose and feet which usually as inflammation of the blood vessels in the skin (erythema), acrocyanosis and ulceration. Other conditions to exclude are Hepatocutaneous syndrome (disorder of the skin caused by liver disease); Erythema exsudativum Multiforme (response to infections or medications); Toxic Epidermal Necrolysis (blistering and peeling); Dermatomyositis (skin rash caused by a muscle disease), disseminated intravascular coagulation (DIC) - bleeding into the skin. Systemic Lupus Erythematosus (SLE); Lymphoreticular neoplasms (cancer caused by propagation of erythrocytes in the Lymphs); Frostbite; Lead poisoning; and Pemphigus (an autoimmune disorder).
A diagnosis of anemia should be detected from other causes of red blood cell destruction/loss of blood tests to distinguish it from warm antibody hemolytic anemia (autoimmune disease). Macroscopic hemagglutination (clumping of red blood cells), in-vitro-cause Rouleaux formation (stacks of red blood cells, as with coin roll); Imitation of agglutination of erythrocytes (red blood cells clumping) on a glass slide.
The condition in which the skin color is yellow, as well as the mucous membranes; This is due to excessive amounts of bilirubin.
The term for organisms living in the test tube
The removal and destruction of red blood cells
Associated with a disease of unknown origin, that may or may not spontaneously emerged
A condition in which the spleen is enlarged
The term for a rapid heart beat
A medical condition in which the patient has an abnormally fast heartbeat
Something in relation with the whole body and not just one part or organ specific that
A red blood cell that carries oxygen
A condition of the blood in the normal red blood cell counts or hemoglobin are missing.
The process of removing all or part of a body part; Usually refers to an extremity (arm or leg) and is carried out for medical reasons.
a) antibodies, that natural response to an infection or the presence of foreign micro-organisms are created as an animal; These antibodies cause that the organisms to clump together. (b) substances or antibodies to clump together the specific organisms cause; Usually causes causes clumping of the organism that it produced in the first place.
The grouping of certain cells, molecules or particles in a field or lumps.
A protein in the body, which is intended to combat the disease; Antibodies are brought by the presence of specific antigens in the system.
Any disease of the animal body produce antibodies used against themselves.
Fibres, to combine the elements that would not normally be combined.
The process some irritation on a blemish to get there way.
The protein that moves oxygen into the blood
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